The significant colonial entrance building of Hotel De Syloia was constructed in 1936, during the French colonial era in Vietnam. Ms. Syloia was a French architect living and working in Hanoi. With her husband she designed and built their residence at 17A Tran Hung Dao.

In 1995 a young Vietnamese couple fell in love with the house, and immediately bought it. They turned the house into a small boutique hotel, gently restoring and extending it with a restaurant. Naming it Hotel De Syloia is a tribute to the architect Syloia.

At the time, Hotel De Syloia and the Metropole Hotel, were the first hotels in Hanoi to open their doors to foreigners.

In 2019 Hotel De Syloia and the Cay Cau Restaurant were thoroughly renovated, in order to produce up-to-date and luxurious standards, but with the utmost respect to the original house. The entrance building and outdoor area have been kept exactly the same, in order to maintain the original heritage and the special ambience of the hotel.

Every room of the hotel has been enhanced with its own carefully selected painting. All paintings are originals, painted by Vietnamese artists.